Which medications in the drug class Alpha2-Adrenergic Agonists are used in the treatment of Multiple Sclerosis?

Updated: Oct 08, 2019
  • Author: Christopher Luzzio, MD; Chief Editor: Jasvinder Chawla, MD, MBA  more...
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Alpha2-Adrenergic Agonists

Tizanidine (Zanaflex) is a centrally active alpha2 -adrenergic agonist that is also used to treat spasticity in patients with MS. It can be used alone or in combination with baclofen.

Tizanidine (Zanaflex)

This centrally acting alpha-adrenergic agonist is presumed to decrease spasticity by increasing presynaptic inhibition of motor neurons. Tizanidine has effects similar to those of baclofen, but it produces less weakness and more sedation. This drug can be titrated starting with 2 mg, with maximum doses of 36 mg/day.

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