Which medications in the drug class Dopamine Agonists are used in the treatment of Multiple Sclerosis?

Updated: Oct 08, 2019
  • Author: Christopher Luzzio, MD; Chief Editor: Jasvinder Chawla, MD, MBA  more...
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Dopamine Agonists

Amantadine is approved for the prophylaxis and treatment of influenza A and Parkinson disease and has been used off-label to relieve fatigue in patients with MS. It has relatively few side effects and is well tolerated .


Amantadine is not FDA approved for use in MS, but dosages of 100 mg given orally twice a day have commonly been used for fatigue. The mechanism by which amantadine counteracts fatigue in MS patients is unclear.

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