Which findings on EEG are characteristic of pyridoxine-responsive seizures?

Updated: Oct 03, 2019
  • Author: Rosalia C Silvestri-Hobson, MD; Chief Editor: Selim R Benbadis, MD  more...
  • Print
Answer

Answer

In addition to neonatal seizures and reported infantile spasms from Japan, the phenotypic presentation for pyridoxine-responsive seizures includes epileptic encephalopathy of infancy and childhood and should be confirmed by pyridoxine challenge during a therapeutic EEG test. Normalization of follow-up EEGs after seizures response to pyridoxine therapy is the rule. [22] A report by Teune suggests that IV pyridoxine affects EEG background activity with reduction in amplitude and total power in infants younger than age 1 year with therapy-resistant seizures as a nonspecific effect. [23]


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!