What is the role of long-term suppressive therapy in the treatment of herpes labialis?

Updated: Mar 17, 2020
  • Author: Sean P McGregor, DO, PharmD; Chief Editor: William D James, MD  more...
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Long-term suppressive therapy should be considered in patients with frequent and severe infections, specifically patients with herpes-associated erythema multiforme or eczema herpeticum. Long-term suppressive therapy has been shown to reduce the number of recurrences and prolong the time to first recurrence. [53]

Long-term suppressive therapy for recurrent herpes labialis in immunocompetent patients is as follows:

  • Acyclovir 400 mg PO twice daily

  • Valacyclovir 500-1000 mg PO daily

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