What are the phase 1 symptoms of erythema infectiosum (fifth disease)?

Updated: Mar 06, 2020
  • Author: Glenn L Zellman, MD; Chief Editor: Dirk M Elston, MD  more...
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Answer

The exanthem begins with the classic slapped-cheek appearance. The bright red, raised erythema appears abruptly over the cheeks and is marked by nasal, perioral, and periorbital sparing, as demonstrated in the image below. [4] The exanthem may appear like a sunburn, occasionally is edematous, and typically fades over 2-4 days. [1]

Classic slapped-cheek appearance of fifth disease. Classic slapped-cheek appearance of fifth disease.

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