Which patients are at risk for bone marrow failure with erythema infectiosum (fifth disease)?

Updated: Mar 06, 2020
  • Author: Glenn L Zellman, MD; Chief Editor: Dirk M Elston, MD  more...
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In patients who are immunocompromised and have little defense against PV-B19, a prolonged viremia may occur, affecting all cell lines of the bone marrow. Immunodeficient states that can lead to bone marrow failure include the following:

  • HIV infection

  • Congenital immunodeficiency syndromes

  • Acute lymphocytic leukemia [14]

  • Immunosuppressive or cytotoxic therapy

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