What is the global prevalence of erythema infectiosum (fifth disease)?

Updated: Mar 06, 2020
  • Author: Glenn L Zellman, MD; Chief Editor: Dirk M Elston, MD  more...
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Erythema infectiosum occurs worldwide, especially in temperate climates, with various strains implicated. [26] Antiparvovirus IgG is found equally among Americans, Asians, and Europeans. [27]

Worldwide, epidemics of erythema infectiosum tend to occur in the late winter or early spring, with incidence peaking cyclically every 4-7 years. Approximately 60% of adults are seropositive for PV-B19 by age 20 years. Infection rates vary from 20-50% in schools and households during outbreaks. [28, 29, 30]

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