What is the prevalence of erythema infectiosum (fifth disease) in the US?

Updated: Mar 06, 2020
  • Author: Glenn L Zellman, MD; Chief Editor: Dirk M Elston, MD  more...
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Although sporadic cases of erythema infectiosum occur, outbreaks are more common. Up to 60% of the population is seropositive for anti ̶ human PV-B19 IgG by age 20 years. The incidence peaks in winter and early spring. [7] Human PV-B19 epidemics appear to occur in a cyclical fashion every 4-7 years and are estimated to affect 30-50% of US households. Community epidemics usually last 3-6 months. Subclinical infections are common. Adults with occupational exposures to children, such as teachers or daycare workers, have a higher risk for PV-B19 seroconversion compared with the general population. [25]

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