What are the indications of fetal transmission of erythema infectiosum (fifth disease)?

Updated: Mar 06, 2020
  • Author: Glenn L Zellman, MD; Chief Editor: Dirk M Elston, MD  more...
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Answer

Fetal transmission may result in severe anemia with resultant congestive heart failure and fetal hydrops. This occurs in fewer than 10% of primary maternal infections. Studies report a 1-9% risk of fetal death in pregnant women exposed to active human parvovirus infection, with a greater risk of fetal loss in early pregnancy. [15] Approximately one half of women of childbearing age are seropositive; therefore, they are immune and are of no risk to the fetus. No evidence suggests specific congenital malformations due to in-utero exposure to human PV-B19. [16, 17]


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