Which specialized tests are performed in the diagnosis of erythema infectiosum (fifth disease)?

Updated: Mar 06, 2020
  • Author: Glenn L Zellman, MD; Chief Editor: Dirk M Elston, MD  more...
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The diagnosis of erythema infectiosum usually is based on clinical presentation alone, and a workup for patients with the classic presentation is not necessary. For patients with other signs or symptoms associated with human parvovirus (PV) B19 or for exposure in a woman who is pregnant, confirmation of infection may be helpful and can be accomplished with the following specialized tests [5, 6, 7] :

  • IgM assays - Enzyme-linked immunosorbent assay (ELISA), radioimmunoassay (RIA)

  • Dot blot hybridization

  • Polymerase chain reaction (PCR) assay

  • Loop-mediated isothermal amplification

See Workup for more detail.

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