Varicella-zoster immune globulin (VariZIG) is indicated for which high-risk groups?

Updated: Aug 31, 2020
  • Author: Anthony J Papadopoulos, MD; Chief Editor: Dirk M Elston, MD  more...
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Varicella-zoster immune globulin (VariZIG), a human immunoglobulin preparation, is indicated for use in highly susceptible, VZV-exposed immunocompromised or immunosuppressed populations.

High risk groups include:

  • Immunocompromised children and adults

  • Newborns of mothers with varicella shortly before or after delivery

  • Premature infants

  • Infants less than one year of age

  • Adults without evidence of immunity

  • Pregnant women

VZIG given within 10 days (ideally within 96 hours) of exposure can modify the course of disease but does not prevent it. Maximal effectiveness is seen with administration as soon as possible after exposure. [31]

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