What assays provide serologic evidence of immunity to chickenpox (varicella) (varicella-zoster virus) (VZV)?

Updated: Aug 31, 2020
  • Author: Anthony J Papadopoulos, MD; Chief Editor: Dirk M Elston, MD  more...
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Serologic evidence of immunity (native immunoglobulin G formation) to VZV can be achieved through a number of different assays, including the following:

  • Enzyme immunoassay

  • Indirect fluorescent antibody

  • Complement fixation

  • Fluorescent antibody to membrane assay

  • Latex agglutination test

Enzyme immunoassay, fluorescent antibody to membrane assay, and indirect fluorescence are not widely available, and complement fixation is not highly sensitive for VZV. The latex agglutination test is the most popular serologic assay for determining exposure and immunity to VZV.

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