Is drug resistance a concern in scabies treatment?

Updated: Oct 13, 2020
  • Author: Megan Barry, MD; Chief Editor: Dirk M Elston, MD  more...
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Observations, however, have noted emerging drug resistance to oral ivermectin and 5% permethrin. [77] Drug resistance is emerging as a concern with repeated administration. Clinical resistance has not been documented for permethrin use, but it has been documented in 2 people with crusted scabies who had repeated regimens of multiple doses of ivermectin.7 Thus, the need to define molecular mechanisms of drug resistance in scabies mites is urgent, as is the development and assessment of alternative therapeutic options. [78]

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