What causes xerosis in patients with end-stage renal disease (ESRD)?

Updated: Mar 05, 2020
  • Author: Julia R Nunley, MD; Chief Editor: Dirk M Elston, MD  more...
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Because many of the cutaneous changes are similar to those induced by retinoids, hypervitaminosis A also has been implicated as an etiologic culprit. Hypervitaminosis A is common in the dialysis patient; however, the epidermal vitamin A content in patients who have ESRD with xerosis is no different from in patients without xerosis. To date, the exact cause of xerosis in ESRD remains unknown. Perhaps the perceived roughness results from a uremia-induced alteration in corneocyte maturation. Many patients respond to routine use of emollients.

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