Which medications in the drug class Immunomodulators are used in the treatment of Porokeratosis?

Updated: Oct 09, 2020
  • Author: Amarateedha Prak LeCourt, MD; Chief Editor: William D James, MD  more...
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These agents modulate processes that promote immune reactions resulting from diverse stimuli.

Imiquimod 5% cream (Aldara, Zyclara)

Imiquimod induces the secretion of interferon-alpha and other cytokines; its mechanism of action is unknown.

Ingenol mebutate topical (Picato)

Ingenol mebutate is an extract from the sap of the noninvasive weed Euphorbia peplus. Its direct effect is related to destruction of the plasma membrane, swelling of the mitochondria, and then cell death via necrosis. It has been shown to have efficacy in the treatment of porokeratosis of Mibelli, used for 3 days for 2 cycles 1 month apart.

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