Which clinical history findings are characteristic of linear porokeratosis?

Updated: Oct 09, 2020
  • Author: Amarateedha Prak LeCourt, MD; Chief Editor: William D James, MD  more...
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Answer

Linear porokeratosis lesions typically develop during infancy or early childhood and may represent a segmental form of disseminated superficial porokeratosis (DSP). [20, 62] Females are slightly more likely to be affected than males. [34] Lesions arise usually as unilateral reddish brown patches or linear keratotic papules and plaques that are typically distributed along the lines of Blaschko, suggesting cutaneous mosaicism. Less commonly, patients may have bilateral involvement with a generalized or systematized forms.

All cases of linear porokeratosis have a higher risk of malignant degeneration than other forms of porokeratosis, possibly because of the allelic loss hypothesized to be at fault for the formation of the lesions.


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