Which medications in the drug class Retinoid-like Agents are used in the treatment of Gram-Negative Folliculitis?

Updated: Aug 07, 2019
  • Author: Mordechai M Tarlow, MD; Chief Editor: William D James, MD  more...
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Retinoid-like Agents

These agents modulate keratinocyte differentiation and decrease sebum production.

Isotretinoin (Claravis, Amnesteem, Sotret, Myorisan)

An oral agent that treats serious dermatologic conditions, isotretinoin is synthetic 13-cis isomer of naturally occurring tretinoin (trans-retinoic acid). Both agents are structurally related to beta-carotene. Isotretinoin decreases sebaceous gland size and sebum production. It may inhibit sebaceous gland differentiation and abnormal keratinization.

A US Food and Drug Administration–mandated registry is now in place for all individuals prescribing, dispensing, or taking isotretinoin. For more information on this registry, see iPLEDGE. This registry aims to further decrease the risk of pregnancy and other unwanted and potentially dangerous adverse effects during a course of isotretinoin therapy.

Female patients must sign an informed consent that they will use contraceptives during treatment course and for 30 days after discontinuing therapy.

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