Which medications in the drug class Antihistamines, First Generation are used in the treatment of Chronic Urticaria?

Updated: Jul 31, 2018
  • Author: Marla N Diakow, MD; Chief Editor: William D James, MD  more...
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Antihistamines, First Generation

First-generation antihistamines compete with histamine at the tissue-receptor level, preventing it from carrying out its mediator functions in urticaria.

Diphenhydramine (Benadryl, Diphenhist, Allerdryl)

Diphenhydramine is given for symptomatic relief of symptoms caused by release of histamine in allergic reactions.

Hydroxyzine (Vistaril)

Hydroxyzine antagonizes H1 receptors in the periphery. It may suppress histamine activity in subcortical region of the central nervous system (CNS). Hydroxyzine is available in 10-, 25-, and 50-mg tablets or capsules and in a 100-mg capsule. The suspension is 25 mg/5 mL, and the syrup is 10 mg/5 mL (tsp).

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