Which medications in the drug class Topical Phosphodiesterase-4 (PDE-4) Inhibitors are used in the treatment of Atopic Dermatitis?

Updated: Apr 26, 2021
  • Author: Brian S Kim, MD, MTR, FAAD; Chief Editor: William D James, MD  more...
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Topical Phosphodiesterase-4 (PDE-4) Inhibitors

A topical PDE-4 inhibitor is a nonsteroidal option for atopic dermatitis treatment.

Crisaborole topical (Eucrisa)

PDE-4 inhibitors allow for cyclic adenosine monophosphate (cAMP) to remain intact in order to decrease the proinflammatory response (eg, cytokine release) associated with atopic dermatitis. Crisaborole is indicated for mild-to-moderate atopic dermatitis in adults and children aged 3 months or older.

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