Which medications in the drug class Antifibrinolytic Agents are used in the treatment of Acquired Angioedema Due to C1 Inhibitor Deficiency?

Updated: May 20, 2020
  • Author: Amanda T Moon, MD; Chief Editor: William D James, MD  more...
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Antifibrinolytic Agents

Antifibrinolytic agents act through the inhibition of plasmin. They tend to be more effective than androgens for prophylaxis.

Aminocaproic acid (Amicar)

Aminocaproic acid is a lysine analog that inhibits fibrinolysis via inhibition of plasminogen activator substances and, to a lesser degree, through antiplasmin activity.

This agent is widely distributed. Half-life is 1-2 h. Peak effect occurs within 2 h. Hepatic metabolism is minimal. It can be used PO or IV.

Tranexamic acid (Cyklokapron, Lysteda)

An alternative to aminocaproic acid, tranexamic acid inhibits fibrinolysis by displacing plasminogen from fibrin.

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