Which physical findings are characteristic of acquired angioedema (AAE) due to C1 inhibitor (C1-INH) deficiency (C1-INH-AAE)?

Updated: May 20, 2020
  • Author: Amanda T Moon, MD; Chief Editor: William D James, MD  more...
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The clinical presentation is not distinguishable from hereditary angioedema. Physical signs include overt, noninflammatory swelling of the skin and mucous membranes. Although urticaria does not usually occur, occasionally, erythema or mild urticarial eruptions may precede the edema.

When looking at reports of different rates of recurrence at specific sites, hereditary angioedema has a tendency to present with more extremity involvement than does acquired angioedema, which presents more with face involvement than limb involvement. Acute abdominal pain due to edema of the gastrointestinal mucosa is less reported in acquired angioedema (30-50%) when compared with hereditary angioedema, in which it is reported in up to 80%. [10, 11]

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