What is the role of CT scanning in the workup of cystic fibrosis (CF)?

Updated: Sep 28, 2020
  • Author: Girish D Sharma, MD, FCCP, FAAP; Chief Editor: Kenan Haver, MD  more...
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Though chest CT scanning is not yet advised as a routine modality in patients with CF and there are concerns about exposure to radiation and the high cost of the procedure, chest CT scanning has been used to diagnose lung involvement, such as an onset of bronchiectasis. High-resolution chest CT scans are reported to be more sensitive than traditional spirometry in detecting changes in lung disease severity. In a recently published prospective study of 81 children with CF, Brody chest scan scores and Wisconsin and Brasfield chest radiograph scores were significantly associated with future lung disease severity. [37] Such quantitative chest imaging has a potential to help clinicians to identify patients at risk of future lung disease progression. CT mosaic attenuation is associated with lung disease. [38]

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