What are the criteria for the diagnosis of cystic fibrosis (CF)?

Updated: Sep 28, 2020
  • Author: Girish D Sharma, MD, FCCP, FAAP; Chief Editor: Kenan Haver, MD  more...
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The diagnosis of cystic fibrosis (CF) is based on typical pulmonary manifestations, GI tract manifestations, a family history, and positive sweat test results.

Requirements for a CF diagnosis include either positive genetic testing or positive sweat chloride test findings (>60 mEq/L) and 1 of the following:

  • Typical chronic obstructive pulmonary disease

  • Documented exocrine pancreatic insufficiency

  • Positive family history (usually affected sibling)

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