How does the prevalence of cystic fibrosis (CF) vary by sex?

Updated: Sep 28, 2020
  • Author: Girish D Sharma, MD, FCCP, FAAP; Chief Editor: Kenan Haver, MD  more...
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Compared with males, females with cystic fibrosis have greater deterioration of pulmonary function with increasing age and younger mean age at death. [19] Although it has been suggested that the increase in hormone secretion with puberty in females may interfere with the defense mechanisms of the immune system, thereby promoting progressive pulmonary involvement, the immune system in patients with cystic fibrosis is fundamentally intact.

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