Which medications in the drug class Anticholinergic Agents are used in the treatment of Pediatric Asthma?

Updated: Jan 08, 2019
  • Author: Girish D Sharma, MD, FCCP, FAAP; Chief Editor: Kenan Haver, MD  more...
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Answer

Anticholinergic Agents

The long-acting anticholinergic agent, tiotropium, may be considered for long-term maintenance therapy, but not for acute treatment of asthma exacerbations.

Tiotropium (Spiriva Respimat)

Tiotropium is a long-acting antimuscarinic agent, often referred to as an anticholinergic. Inhibits M3-receptors at smooth muscle, leading to bronchodilation. It is indicated for long-term, once-daily, maintenance treatment of asthma in patients aged ≥6 years.

Ipratropium (Atrovent)

Chemically related to atropine, ipratropium has antisecretory properties and, when applied locally, inhibits secretions from serous and seromucous glands lining the nasal mucosa. The MDI delivers 17 mcg/actuation. Solution for inhalation contains 500 mcg/2.5 mL (ie, 0.02% solution for nebulization). It is not approved for asthma, but off-label use for acute exacerbations of asthma in addition to beta2-agonist therapy has been described in the literature. It is a short-acting anticholinergic agent with an onset of 15 minutes.


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