What is the role of fraction of exhaled nitric oxide (FeNO) measurement in the evaluation of pediatric asthma?

Updated: Jan 08, 2019
  • Author: Girish D Sharma, MD, FCCP, FAAP; Chief Editor: Kenan Haver, MD  more...
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Measuring the fraction of exhaled nitric oxide (FeNO) has proved useful as a noninvasive marker of airway inflammation, in order to guide adjustment of the dose of inhaled corticosteroids. In one study involving home monitoring of FeNO and symptom scores, the 2 correlated. Further, in some patients, the FeNO rose before significant exacerbations of the asthma [44] ; thus, although studies of FeNO in large groups have either shown it to be helpful or not, it may be a useful method of evaluating therapy in individual patients. Due to the high cost of equipment, FeNO measurement is used primarily as a research tool at present.

Measuring the level of interleukin-5 in exhaled breath condensate is a possible way of titrating asthma progress, according to one study. In a longitudinal study of 40 asthmatic children aged 6-16 years, asthma control score and level of interleukin-5 were significant predictors of an asthma exacerbation. [45]

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