What factors increase the risk for wheezing in pediatric asthma?

Updated: Jan 08, 2019
  • Author: Girish D Sharma, MD, FCCP, FAAP; Chief Editor: Kenan Haver, MD  more...
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Answer

Children exposed to higher maternal stress during the pre- and postnatal period were reported to be at higher risk for wheeze. This was only true in non-atopic mothers. [30]

A 2012 Danish study reported an association between maternal obesity (BMI ≥35 and gestational weight gain ≥25 kg) during pregnancy with increased risk of asthma and wheezing in the offspring. [31]

Results of a prospective birth cohort study of 568 pregnant women and their offspring showed that postnatal bisphenol A (BPA) exposure in the first years of a child's life is associated with significantly increased risk for wheeze and asthma. Feeding bottles, sippy cups, or other containers designed for infants may contain it. The study also found, however, that fetal exposure to BPA during the third trimester of pregnancy was inversely associated with risk for wheeze in offspring at age 5 years. [32, 33]


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